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Bursting in cerebellar stellate cells induced by pharmacological agents: Non-sequential spike adding

Fig 6

Square-wave bursting in the CSC model defined by the full system (1) when gHVA is varied.

A). Magnification of the set of isolas of square-wave BPOs shown within the box in Fig 5A. Each isola is an envelope of stable periodic orbits (solid) on the top that becomes unstable (dotted) either at a saddle-node bifurcation of periodic orbits (SNPi, i = 3, …) or period-doubling bifurcation (PDj, j = 1, …) to the right and left of each isola in a non-orchestrated manner (i.e., in a non-consistent pattern). The number of spikes of active phases of BPOs associated with these isolas is indicated with a number on top. B) Time courses of two square-wave BPOs when the number of spikes per burst is 14 (top) and 10 (bottom) obtained at gHVA = 0.232 μS.cm−2 and gHVA = 0.253 μS.cm−2, respectively.

Fig 6

doi: https://doi.org/10.1371/journal.pcbi.1008463.g006