Bursting in cerebellar stellate cells induced by pharmacological agents: Non-sequential spike adding
Fig 2
Review of the main four features of the full system (1): A) Type I excitability with a SNIC bifurcation during pre- (faded lines) and post-runup (dark lines). Solid (dashed) black/gray lines correspond to branches of stable/unstable equilibria, respectively; solid green lines correspond to envelopes of stable limit cycles. B) Non-monotonic first-spike latency with respect to the holding potential (Vhold) during pre- (gray) and post-runup (back). C) The boundary between responsive (to the right) and non-responsive (to the left) regimes when a pair of inhibitory and excitatory pre-synaptic inputs of various magnitudes are applied during pre- (C1) and post-runup (C2). D) color-maps of the no-spiking (NS), single spiking (SS) and tonically spiking (TS) regimes during pre- (D1) and post-runup (D2), color-coded based on the duration of the first-spike latency calibrated according to the color-bar to the right. The system generates a single spike for Itest < ISNIC when the stable manifolds of the saddle and saddle-node do not coincide and the initial condition lies between them. Time series simulations of these properties are available in [13, 16, 17].