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Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection
Fig 5
Predictions of population level synergy.
(A-F) The predicted population level and overall synergy over a range of drug concentrations (see text for details). (G, H) The predicted overall and population level synergy for varying mean TMPRSS2 expression and fixed mean (
= 11.5) Cathepsin B/L expression (G) and for varying mean Cathepsin B/L expression and fixed mean (
= 11.5) TMPRSS2 expression at two different drug concentrations (H). The drug concentrations were normalised by the respective γ values. In A-C and G-H, 
= 1.2 x 105 copies/cell and 
= 2.4 x 105 copies/cell. In D-F, 
= 4 x 104 copies/cell, 
= 4 x 104 copies/cell. In G-H, DT/γT = DC/γC = 10. The parameters are listed in S1 Table.
doi: https://doi.org/10.1371/journal.pcbi.1008461.g005