A dual-feedback loop model of the mammalian circadian clock for multi-input control of circadian phase
Fig 7
Comparison the MPC algorithm using different control inputs.
The output of the MPC simulation using the linear approximation from the ipPRC (Eq 20) for different combinations of parameters. A. KL001 (single input on the negative loop), B. Longdaysin (single input on the negative loop), C. KL001 and FBXW7-α (multi-input on the negative and positive loop), D. Longdaysin and FBXW7-α (multi-input on the negative and positive loop), E. KL001 and Longdaysin (multi-input on the negative loop). Top panels in each subfigure show the phase trajectory of the model (green) in comparison to the reference (dotted gray). Other panels show the PRC of the control input (dashed lines) and control delivered (solid lines) for KL001 (red), Longdaysin (cyan), and FBXW7-α (blue).