A dual-feedback loop model of the mammalian circadian clock for multi-input control of circadian phase
Fig 4
Correlation of amplitude sensitivities of different species to model parameters.
For each model species, we computed the amplitude sensitivity for each of the model parameters. The positive correlations between the amplitude sensitivities for each species showed that the amplitude of different species are most sensitive to similar parameters. As expected, these correlations were strongest between the mRNA and protein of the same species. Strong correlations were also seen within the negative feedback loop. These correlations suggested that the targets which are most effective in controlling amplitude for a single species will similarly be strong targets in affecting the amplitude of the other clock species.