A dual-feedback loop model of the mammalian circadian clock for multi-input control of circadian phase
Fig 3
Period sensitivities to model parameters in each loop.
For every parameter in the model, we plotted the period sensitivity calculated locally at the optimally fit parameter value versus the fit parameter value. The period sensitivity to the parameters in the negative feedback loop (blue) were orders of magnitude greater than those of the positive feedback loop (orange). Since these sensitivities were infinitesimal, the period sensitivity was largely independent of the magnitude of the fit parameter and depended much more strongly on which feedback loop the parameter governs.