A dual-feedback loop model of the mammalian circadian clock for multi-input control of circadian phase
Fig 2
Output oscillations of the model.
The output oscillations in expression concentrations of the model parameterized with the lowest cost parameter set show that the model produces a limit cycle. Each model species is represented by a different color line. The x-axis is in arbitrary time units since time can be rescaled to any desired period. From the expression curves, one can visualize the different model features, including peak-trough ratios, relative abundances, and phase differences, used to fit the parameters. Despite similar underlying physiological processes (transcription, translation, and degradation) corresponding to similar equations, each species has a different resulting waveform, presenting a potentially important model outcome for comparison to other models as experimental techniques improve to have better time-resolution for these expression curves.