Ten simple rules for typographically appealing scientific texts
Fig 5
(A) Text in italics, small caps, or a matching alternative font does not change the type color of the page and emphasizes words within the context while reading. Bold text, uppercase letters, and different colors are more prominent and serve as “entry points” to the text. Using a contrasting alternative font, letter spacing, and underlining words forms an even stronger visual contrast, but is challenging to get looking good. (B) In the era of typewriters, authors were much more limited in using emphasis in their texts. (C) Italic, bold, and small caps should be used as properly designed font variants and not be faked by slanting (making the text look unnatural), making lines thicker (leading to, e.g., shrunken eyes and unbalanced spacing), or scaling capitals (making glyphs skinny). (Disclosure of image manipulation: text typed using a mechanical typewriter was digitized and edited for clarity, and color channels of the RGB image were manipulated to imitate red text from a 2-color ink ribbon).