A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness
Fig 16
Representative time series of viral internalization, replication and release models from Fig 2B.
A sample simulation of the viral replication model in a single epithelial cell. The model is initialized with one unit of internalized virus (U = 1), and the rest of the state variables set to zero (R = 0, P = 0, A = 0). No additional virus internalization occurs during this sample simulation. Dashed line indicates the time of the cell’s transition from the infected to virus-releasing cell type.