A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness
Fig 14
Even simple model extensions and extensions of extensions can produce notably different spatiotemporal emergent features.
(A) Schematic of implementing a modified epithelial cell model using the available modules described in Models and methods (“Main modules”) and add-on modules libraries hosted in the framework public repository. Modules used in a simulation are specified in model specification. The Simple Recovery and Neighbor Recovery model modules are available in the add-on modules library. (B) Distribution of epithelial cells during simulation time using the Simple Recovery (top) and Neighbor Recovery (bottom) models. Cell type colors are the same as in Fig 3A. (C) Number of uninfected cells during simulation time for ten simulation replicas using the Simple Recovery (left) and Neighbor Recovery (right) models.