A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness
Fig 13
Basic integration of an explicit model of hepatitis C virus subgenomic replication in a spatial context presents stochastic outcomes in ten simulation replicas.
(A) Schematic of implementing the integrated HCV model using the available modules described in Models and methods (“Main modules”) and add-on modules libraries hosted in the framework public repository. All main modules are imported except Viral Replication, which is replaced with Integrated HCV. Modules used in a simulation are specified in model specification. The integrated HCV model module is available in the add-on modules library. (B) Distributions of epithelial cells during simulation time for select replicas (labeled “a”, “b” and “c”) using the integrated HCV model. Cell type colors are the same as in Fig 3A. (C) Number of uninfected cells (left) and total extracellular virus (right) during simulation time for ten replicas using the integrated HCV model. Select results shown in (B) are annotated according to replica labels “a”, “b” and “c”.