A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness
Fig 12
Randomly distributed unsusceptible cells inhibit but do not stop spread of infection throughout the tissue.
(A) Distributions of epithelial cells during simulation time (columns) for varying fraction of unsusceptible cells (rows). From top to bottom, replicas were simulated with 10%, 20%, 30%, 40% and 50% of epithelial cells unsusceptible to viral internalization. Cell type colors are the same as in Fig 3A. (B) Number of uninfected cells during simulation time for ten replicas of each fraction of epithelial cells unsusceptible.