A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness
Fig 11
Difference in treatment effectiveness for different simulation replicas for perfect treatment potency (0 viral replication rate multiplier) near the time when the extracellular virus amount would reach its maximum in the untreated case (10000 minutes, 167 hours, 7 days).
(A) Select simulation replicas for this parameter set showing the variety of possible outcomes (treatment effectiveness). Spatial results show the epithelial and immune cell layers, and the extracellular virus field, at 4000, 8000, 12000, 16000, and 20000 minutes (67, 133, 200, 267 and 333 hours, 2 ¾, 5 ½, 8 ⅓, 11 and 14 days). Cell type colors are the same as in Fig 3A. Virus field values are scaled as in Fig 3A. (B) Time series for all simulation replicas for the selected parameter set: Right column, from top to bottom, number of uninfected epithelial cells, number of infected epithelial cells, number of virus-releasing epithelial cells, number of dead cells. Left column, from top to bottom: total amount of extracellular virus, total amount of cytokine, number of immune cells and immune response state variable. All variables except the immune signal plotted on a logarithmic scale vs time.