A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness
Fig 10
Levels of extracellular virus vs time in simulations of a hypothetical drug treatment reducing the viral genome (e.g. RNA for SARS-CoV-2) replication rate (rmax) as a function of drug potency (one minus the viral replication rate multiplier) and time of initiation of treatment.
Extracellular virus is cleared or near-cleared when intervention occurs soon after infection. Parameter values, axis types and time-scale and shading as in Fig 8.