A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness
Fig 9
Number of virus releasing cells vs time in simulations of a hypothetical drug treatment reducing the viral genome (e.g. RNA for SARS-CoV-2) replication rate (rmax) as a function of treatment potency (one minus the viral replication rate multiplier) and time of initiation of treatment.
The number of virus-releasing epithelial cells stays low when the intervention occurs early during infection (when the amount of extracellular virus is increasing rapidly), but continues to increase when the intervention occurs later (when the level of extracellular virus is at or near its maximum in the untreated case). Parameter values, axis types and time-scale and shading as in Fig 8.