A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness
Fig 5
Sensitivity analysis of the number of uninfected epithelial cells vs time for variations in virus-receptor association affinity kon and immune response delay coefficient βdelay, showing regions with distinct infection dynamics.
Logarithmic pairwise parameter sweep of the virus-receptor association affinity kon and the immune response delay βdelay (×0.01,× 0.1,× 1,× 10,× 100) around their baseline values, with ten simulation replicas per parameter set (all other parameters have their baseline values as given in Table 1). The number of uninfected epithelial cells for each simulation replica for each parameter set, plotted on a logarithmic scale, vs time displayed in minutes. See Fig 4 for the definitions of the classes of infection dynamics.