In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species
Fig 2
Binding affinities of animal species.
(A) ACE2 full sequence alignment of the selected species for the binding region to the S protein (B) Global ΔΔG interaction for different species by adding single residue contributions with respect to hACE2. Green bars for species susceptible to be infected, red bars for species not infected. (C) Per-residue interaction ΔΔG values in kcal/mol with respect to the hACE2 residues. We don't show the results for K353 in this table since it is not on the helical interface and it is only mutated to His in mice.