Neural mass modeling of slow-fast dynamics of seizure initiation and abortion

doi:10.1371/journal.pcbi.1008430

Neural mass modeling of slow-fast dynamics of seizure initiation and abortion

Fig 6

System (1) under stimulation.

Biphasic stimulation with a 0.5 ms pulse width (total pulse duration is 1 ms) is applied to the system in type-1 bursting. Panels (a) and (b) show the energy map of the simulated LFP signal that is lower in the blue region than the yellow region (see the color bar on the right). The energy of the LFP signal was computed by using where n stands for the index of and N for the size of the discrete signal x(n). (a) Only the SOM+ interneurons receive the biphasic perturbation. (b) The pyramidal cell, SOM+ interneurons and PV+ interneurons receive the same biphasic perturbation. Panels (c), (d) and (e) show the time course of the marked stimulation on panels (a) and (b). (c) 15 Hz biphasic stimulation with 10 arb. unit amplitude is applied to the SOM+ interneurons (k_SOM = 1, k_P = k_PV = 0). (d) 15 Hz biphasic stimulation with 10 arb. unit amplitude is homogenously applied to all subpopulations (k_SOM = k_P = k_PV = 1). (e) 25 Hz biphasic stimulation with 10 arb. unit amplitude is homogenously applied to all subpopulations (k_SOM = k_P = k_PV = 1).

doi: https://doi.org/10.1371/journal.pcbi.1008430.g006