Spatial considerations in the resolution of inflammation: Elucidating leukocyte interactions via an experimentally-calibrated agent-based model
Fig 7
Comparison of the in vitro cell tracking experiments of [10] (A,C) with simulations of our calibrated chemotaxis model (B,D).
In (A,B), we illustrate the healthy case, with simulations calibrated using a mean cell velocity of 3.77 μm/min and a mean chemotactic index is 0.39, providing kgrad = 80 and σmem = 1. In (C,D), we illustrate the inflamed (COPD) case, with simulations calibrated using a mean cell velocity of 0.09 μm/min and a mean chemotactic index is 0.04, providing kgrad = 8 and σmem = 1.2. (A,C) Reprinted with permission of the American Thoracic Society. Copyright ©2019 American Thoracic Society. Cite: Sapey et al. (2011) ‘Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease’, American Journal of Respiratory and Critical Care Medicine 183(9), 1176-1186. The American Journal of Respiratory and Critical Care Medicine is an official journal of the American Thoracic Society.