Bridging from single to collective cell migration: A review of models and links to experiments
Fig 5
Cell sorting (left) and wound-healing (right) captured by several distinct computational methods.
(A1) Cells represented by deformable ellipsoids in 3D. Simulations by Hildur Knutsdottir based on code originally created by Eirikur Palsson (A2) Vertex-based simulations using CHASTE open source platform, run by Dhananjay Bhaskar. (A3) CompuCell3D cell-sorting simulations run by Dhananjay Bhaskar. In (A1–A3), there are 2 cell types with differing adhesion strengths to self and other cell type. (B1) and (B2) show deformable ellipsoids and CPM scratch wound models with 2 cell types. Cells with weaker adhesion (red) tend to segregate to the edge of the monolayer, acting as leader cells, and causing fingering of the front. (Compare with [168]). Papers that compare distinct computational platforms include [143].