Bridging from single to collective cell migration: A review of models and links to experiments
Fig 3
Modeling goals can be classified into broad categories that span levels of hierarchy.
Some models attempt to span knowledge of single cell behavior plus interactions to predict emergent multicellular behavior (bottom up, left), whereas others start with observations of tissue dynamics and seek to infer underlying rules, feedbacks, and cell-cell (c-c) interactions that lead to those observations (top down, right).