Inferring evolutionary pathways and directed genotype networks of foodborne pathogens
Fig 4
The structure of the centrality-prevalence space, revealed by the expected value of the positive gain in prevalence.
For every MLVA profile, the point size is shown in proportion to the average change in prevalence. The size is set to one if the change is negative, so that the contribution of all unsuccessful paths with negative change in prevalence is bounded. Colour intensity indicates the estimated density, given the average changes in prevalence for all profiles. The transition region (intense red colour) is shaped by the profiles with high centrality and medium cluster prevalence, i.e., node centrality between 0.0329 and 0.0359, and cluster prevalence between 101.14 and 101.46. The evolutionary paths originating from profiles in this region tend to produce the higher average change in prevalence, that is, these paths develop from right to left and from bottom to top.