Inferring evolutionary pathways and directed genotype networks of foodborne pathogens
Fig 3
Structure-function relationship in the genotype networks, mapping the centrality of profiles (x-axis) and their average cluster prevalence (y-axis).
The size of each point is proportional to the size of its corresponding cluster. The centrality is measured with respect to the complete undirected genotype network. The colour shows the genetic distance of a profile to the reference profile (in orange, see Fig 2), with grey points indicating disconnected profiles. The gradient of colouring indicates an evolutionary trend from low-to-high centrality (left to right) and then a reverse in direction from high to medium centrality (right to left). During this trend, the average prevalence of the node clusters is increasing. Consequently, two branches can be distinguished: (i) from weakly-prevalent and peripheral nodes (the bottom-left corner), towards a region comprising the profiles with high centrality (between 0.033 and 0.036) and medium cluster prevalence (between 12 and 32.1), and (ii) from this region towards the reference profile (in orange), in the direction of increasing prevalence (bottom to top) but decreasing centrality (right to left). The three case studies are shown in magenta, blue, and red, as well as the longest path (dashed black), with the source profile of these paths circled with the colour of the path.