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Active probing to highlight approaching transitions to ictal states in coupled neural mass models

Fig 1

Modified neural mass model.

(a) Representation of each coupled neuronal population and corresponding subpopulations. Excitatory interneurons are implicitly represented as the self-feedback loop from main pyramidal cells (EXCi to itself). Each model settings consists of either (I) unilateral (s2) or (II) simultaneous bilateral low-frequency probing stimulation (s1 and s2), while slowly changing one parameter towards ictal activity–A1, B1 or K.

Fig 1

doi: https://doi.org/10.1371/journal.pcbi.1008377.g001