Leveraging functional annotation to identify genes associated with complex diseases
Fig 4
Function constriant and tissue-specificity of identified trait-associated genes.
A) Higher pecentage of significant genes by T-GEN have pLI scores larger than 0.99 for genes identified in leass than 5 traits. Considering the number of traits that each identified gene is associated with, all significant trait-associated genes were groupped into three categories. The bar plot shows the percentage of genes identified by each method having larger pLI scores (>0.99) in each category. Error bars indicate the standard error calculated using bootstraping (120 traits each time, for 20 times). B) More genes were identified by T-GEN as trait-associated in tissues most enriched for genetics signals. In tissues with the highest heritability enrichment and also other tissues, the numbers of identified trait-associated genes were compared across all five methods. Each barplot shows the mean value of the numbers of identified trait-associated genes across 207 traits in the LD Hub.