Mutation bias interacts with composition bias to influence adaptive evolution
Fig 2
Accessible mutational paths exhibit composition bias toward transversions.
(a) The black bars show the distribution of composition bias across entire landscapes. The white bars show the distribution of composition bias across accessible mutational paths to the global peak, starting from the 10% of binding sites with the lowest affinities in each landscape. Gray indicates the overlap in the distributions. Data pertain to all 746 landscapes. (b) Composition bias of accessible mutational paths, with landscapes grouped by DNA binding domain structural class. Numbers in parentheses indicate the number of transcription factors per class in our dataset.