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Optimising age coverage of seasonal influenza vaccination in England: A mathematical and health economic evaluation

Fig 6

Estimated savings against additional administered vaccines for alternative vaccine programmes (relative to an at-risk only vaccination programme).

The plotted points represent estimates for a single vaccine programme, with one QALY valued at £30,000 and the vaccine cost set at the threshold value that 90% of simulation replicates remain cost-effective. The red dashed line with circle markers corresponds to young-age centric strategies. Numerical values contained within the circle markers state the upper bound of age coverage represented by that particular young-age centric strategy (e.g. the marker containing “20” represents a strategy covering those between 2 to 20 years of age). The blue solid line with inverted yellow triangle markers corresponds to elder-age centric strategies. Numerical values contained within the inverted triangle markers express the lower bound of age coverage represented by that particular elder-age centric strategy (e.g. the marker containing “20” represents a strategy covering those aged 20 years old and above). Standalone young-age centric strategies perform well, forming a rough upper bound on potential savings. In contrast, standalone elder-age centric strategies typically display less effective performance.

Fig 6

doi: https://doi.org/10.1371/journal.pcbi.1008278.g006