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Protein-protein interactions in neurodegenerative diseases: A conspiracy theory

Fig 22

Patient pathology dynamics in primary tauopathy.

(Left) Phase plane with four equilibria. Homogeneous dynamics of the toxic states. Note that this is a two-dimensional slice of the four-dimensional phase space. (Right) When four different states co-exist, only the fully toxic state is stable as shown by the time-dynamics plot. (Parameters: a₀ = b₀ = a₁ = a₂ = b₁ = b₂ = 1, , b₃ = 1/2).

doi: https://doi.org/10.1371/journal.pcbi.1008267.g022