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A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors

Fig 7

Dynamics of prognostic measures obtained from the model.

A,B) Time evolution of spherical rim width and surface regularity for 100 simulations with parameters from Table 1. The solid line is the average value and the dashed line the standard deviation. 2D reconstructions correspond to characteristic upper and lower values of each variable. Basal parameters, measured in hours, for each subplot are: A1) τ^rep = 94.2 h, τ^death = 170.8 h, τ^mut = 99.4 h, , A2) τ^rep = 184.9 h, τ^death = 230.1 h, τ^mut = 120.0 h, , B1) τ^rep = 104.8 h, τ^death = 323.5 h, τ^mut = 222.7 h, , B2) τ^rep = 158.7 h, τ^death = 54.2 h, τ^mut = 197.7 h, .

doi: https://doi.org/10.1371/journal.pcbi.1008266.g007