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A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors

Fig 6

Dynamical behavior of tumor heterogeneity.

A) Evolution of Shannon and Simpson’s indexes for a typical run. Basal rates for this run are τ^rep = 242.6 h, τ^death = 213.3 h, τ^mut = 221.6 h, . The other parameters are those of Table 1. B) Abundance of each subtype in logarithmic scale as a function of time. C) Superposition of final subtype abundance for all simulated tumors. D) Final abundance per subtype per simulation. Each row corresponds to one subtype, in the same order as above. Color indicates end-point abundance.

doi: https://doi.org/10.1371/journal.pcbi.1008266.g006