A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors
Fig 4
Tumor slice and simulated profiles.
A) Two-dimensional slice of a T1-weighted post-contrast MRI scan of an actual GBM. B) Two-dimensional slices of different simulated tumors. Each simulated tumor corresponds to the final state (100 cm3) of a different running of the model. Basal parameters for each simulation are: 1) τrep = 242.6 h, τdeath = 213.27 h, τmut = 221.6 h, , 2) τrep = 206.7 h, τdeath = 90.5 h, τmut = 219.5 h,
, 3) τrep = 184.2 h, τdeath = 325.4 h, τmut = 186.5 h,
, 4) τrep = 233.5 h, τdeath = 143.0 h, τmut = 175.9 h,
, 5) τrep = 201.2 h, τdeath = 295.5 h, τmut = 132.3 h,
, 6) τrep = 219.8 h, τdeath = 177.2 h, τmut = 87.33 h,
. Other parameters are listed in Table 1.