Models of SIV rebound after treatment interruption that involve multiple reactivation events
Fig 3
Representative examples of the fits of the mixed-effects model to the VL rebound time series.
(A) The top panels show the VL data (black dots connected by black lines, with red dots for left-censored observations; the grey dots are ignored) taken from macaques where ART was started at different days post infection (DPI), and the model prediction (blue lines: posterior mean; dark blue band: 50% credible interval (CrI), light blue band: 50% posterior predictive interval). The estimated time-to-rebound (τ) is given by the vertical black line (gray band: 50% CrI). (B) The bottom panels show posterior predictive distributions of the time-to-rebound. The green distributions (c) are conditioned on the estimated time of the initial recrudescence event, the purple distributions (u) are unconditional. Model fits and posterior predictive distributions for all 25 macaques are shown in S1 Fig.