Graph-theoretical formulation of the generalized epitope-based vaccine design problem
Table 1
Integer linear program formulation of the generalized epitope vaccine design problem.
It results in a cocktail of |T| polypeptides each composed of at most k epitopes. Together, the polypeptides cover at least Θs pathogens and Θa MHC alleles, and contain epitopes with an average pathogen conservation of at least Γ.