Graph-theoretical formulation of the generalized epitope-based vaccine design problem
Fig 9
Effect of different immunogenicity predictors on optimized vaccines.
Each scatter plot shows the immunogenicity predicted by a certain method (y axis), when the ten-epitopes string-of-beads vaccine was designed optimizing the immunogenicity predicted by a different method (x axis). The diagonal shows the immunogenicity distribution of the optimized vaccines. The color of each point indicates the cleavage score of the vaccine (brighter is larger). Inside each scatter plot, we report the intersection-over-union (IoU) of the epitopes, the number of shared epitopes between vaccines of similar cleavage score indicating median and 25th and 75th percentile in parentheses, and the correlation coefficient (Pearson or Spearman depending on the plot) with its p-value against the null hypothesis of no correlation.