Graph-theoretical formulation of the generalized epitope-based vaccine design problem
Fig 5
Cocktail of mosaic proteins compared to an equivalent string-of-beads vaccine.
We designed a cocktail (blue) of four polypeptides (cyan) that covers 99% of the pathogens, even though the single fragments only cover between 85 and 95%. The orange and red bars correspond to an epitope mixture designed by OptiTope and a mosaic with the same number of amino acids respectively; the former was required to reach 99% pathogen coverage, and the latter was unconstrained.