Graph-theoretical formulation of the generalized epitope-based vaccine design problem
Fig 4
Decrease in cleavage score by randomly permuting string-of-beads vaccines.
(a) For each vaccine in the Pareto frontier of each bootstrap, we created 50 new string-of-beads by randomly permuting its epitopes and compared the cleavage scores of the two vaccines. The black dots in the box plots show the median decrease. (b) cleavage score and immunogenicity of the original vaccine with optimized ordering.