Mathematical model predicts response to chemotherapy in advanced non-resectable non-small cell lung cancer patients treated with platinum-based doublet
Fig 6
Comparison of all eight chemotherapy treatment schedules.
For four combinations of asr and ars, the heatmap shows the long-term response (represented by the colors) to palliative chemotherapy administered using eight different schedules. On x-axis we have different patient schedules and on y-axis patient ID. Optimal treatment schedule depends on dynamics of competition between various subclones in a tumor. For example, for high asr and ars, the best outcome gives schedules with drug holidays, whereas for weak competition all schedule gives the same outcome.