Causal network inference from gene transcriptional time-series response to glucocorticoids
Fig 7
Network edge validation using known cis- elements from GTEx v6 lung cis-eQTLs.
A) Enrichment of trans associations in primary lung tissue among p-values from edges inferred by BETS compared to p-values from permutations. B) Quantile-quantile plot of validated edges shows signal enrichment in lung samples when compared to signals from four other tissues in the GTEx v6 study. C) SNPs associated with inferred gene pairs. Genotype-phenotype plots corresponding to the cis-effect (left column), correlation in the GTEx v6 data between cause (y-axis) and effect (x-axis) gene pairs (right column).