MASSpy: Building, simulating, and visualizing dynamic biological models in Python using mass action kinetics
Fig 4
Comparison of free energy and isozyme fractional abundances for carbon sources.
(A) The Gibbs free energy represents the thermodynamic driving force, shifting the metabolic state depending on the carbon source. (B) The glycolytic subnetwork extracted from E. coli iML1515 consists of 12 reactions represented by the 17 enzyme modules. (C) The fractional abundance for each enzyme form can be computed and compared for the different isozyme pairs, providing insight into how the catalytic activity is distributed across the isozymes in glucose and pyruvate growth conditions. The fractional abundances for all enzymes can be found in the supplement (S2 Fig).