A greedy classifier optimization strategy to assess ion channel blocking activity and pro-arrhythmia in hiPSC-cardiomyocytes
Fig 13
Section TdP classification: Confusion matrices obtained for TdP risk classification of 86 compounds after convergence of the algorithm.
Yes: TdP risk. No: No TdP risk. Left: Training set (sample size: 1520) using randomized K-fold cross-validation. Sensitivity = 0.98, Specificity = 0.85 and Accuracy = 0.92. Right: Validation set (sample size: 200). Sensitivity = 1, Specificity = 0.675 and Accuracy = 0.935.