A greedy classifier optimization strategy to assess ion channel blocking activity and pro-arrhythmia in hiPSC-cardiomyocytes
Fig 7
Section Dictionary entries: Electrophysiological biomarkers: Moxifloxacin simulation.
Simulation of the effect of Moxifloxacin at effective free therapeutic plasma concentration (10.96μM, see Table F in S1 Text) on the FP (from one electrode) and intracellular calcium transient (from one well) for two different heterogeneity fields. A finite element mesh of 96-well MEA device from Axion Biosystems was used for this simulation (see right panel of Fig 3).