Capturing cell type-specific chromatin compartment patterns by applying topic modeling to single-cell Hi-C data
Fig 4
Cell cycle effect is captured by topic modeling.
(A) Two-dimensional UMAP projection of topic-cell matrix obtained by applying LDA to Nagano et al. data. (B) Heatmap of Z-scaled average normalized topic assignment values. Rows are annotated by the specificity of the topics. (C) Barplot showing the distribution of inter locus pair distances in the cell cycle stage-specific and general topics. (D) Average LP distances in topics specific to each cell cycle stage group.