Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology
Fig 4
DDA-based peptide quantification of Fc and Fab fragments of IgG subclasses bind to different sub-domains of M1 protein.
All IgG subclasses bind to the M1 protein through their Fc-domains. The S- & C1-domains and the hypervariable domain A of the M1 protein have the highest affinity for IgG subclasses. Only IgG heavy chains were considered.