Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology
Fig 3
The TX-MS based M1-IgG model aligned with that of the streptococcal protein G.
(a-b) Protein G (PDB ID: 1FCC) is shown in red with its binding interface on IgG1 in dark blue. The M1 protein is shown in magenta and dark grey with its binding interface on IgG in light blue. Both proteins share the same binding site on IgGs in CH3 domains and close to CH2.