Tumor vascular status controls oxygen delivery facilitated by infused polymerized hemoglobins with varying oxygen affinity
Fig 4
Artificial mouse tumor growth and resulting biophysical properties after 40 days of growth.
(A) Visualization of cutaways, vessel (blue), tumor (green) and necrotic (red) volume fraction cross sections for artificial mouse tumor growth over 40 days. The tumor shown here was grown in a type A vascular bed. Also shown in this figure are the (B) radius, (C) rate of radial expansion, and (D) necrotic volume percentages for each vessel bed type (Type A-I). Shaded areas in these plots represent a 95% confidence interval across each type of vessel bed configuration. (E) Visualization of combined volume fraction cross sections for selected tumors from each of the vessel bed types (Type A-I). Comparison of (F) RBV and (G) CHb,tis between the tumor and host tissue in the artificial tumor constructs. The letter labels indicate the vessel configuration. The dashed line separates the tumor properties greater than and less than the host properties. For all tumor cross sections the scale bar is 1 mm.