Tumor vascular status controls oxygen delivery facilitated by infused polymerized hemoglobins with varying oxygen affinity
Fig 3
At each time step, blood flow, distribution of nutrients/growth factors and vascular remodeling are computed. The tissue phase remodels at shorter time steps within the main loop. The resulting artificial tumors are transferred to the infusion model. Hemodilution and the HBOC enhanced viscosity modulates flow and vascular adaptation until the microvascular system is stable. After this, HBOC enhanced oxygenation is modeled.