Determining the interaction status and evolutionary fate of duplicated homomeric proteins
Fig 2
The distribution of divergence modes of S. cerevisiae and E. coli paralogous pairs.
The four divergence modes, obligatory-homo, obligatory-hetero, mixed and hetero-others, are described in Fig 1A. (A) The distribution of S. cerevisiae paralogous pairs in PPI data (right panel) and in curated complexes (left panel). Presented are the distributions for different stringencies of analysis, along its 3 steps (Fig 1B). Step-1, paralog assignment, is presented in columns, shaded in green, from low-confidence in pale green to high-confidence paralogs in dark green. Step-2, identifying interactions, also in columns, from white (raw PPI data) to dark grey (filter-3). Step-3, the divergence mode, is presented in rows–the top set of rows represent the flexible criterion (shaded in yellow), and the bottom rows the stringent criterion (dark yellow). The dominant divergence modes, or fates, are highlighted in darker shades of red. (B) The distribution of E. coli paralogous.