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Relations between large-scale brain connectivity and effects of regional stimulation depend on collective dynamical state

Fig 3

Long-range coupling strength C and background drive modulate network phase-coherence and relationships between structural and functional connectivity at baseline.

(A) The global order parameter ρ^global vs. , for different fixed values of C. Error bars are estimated from 100 bootstrap samples of the simulations at each coupling and background drive, and correspond to ± one standard deviation of the bootstrap disribution of ρ^global. (B) The difference between the global and local order parameters, ρ^global − ρ^local, vs. , for different fixed values of C. Error bars are estimated from 100 bootstrap samples of the simulations at each coupling and background drive, and correspond to ± one standard deviation of the bootstrap distribution of ρ^global − ρ^local. (C) Region-by-region PLV matrices for various values of at fixed C = 2.5. The boxed matrices correspond to the red, orange, and yellow working points in Fig 2 and in panels A and B of this figure. (D) The Spearman correlation r_s between structural node strength s^struc and functional node strength s^func vs. at fixed C = 2.5. Empty circles indicate that the correlation was not statistically significant at the p = 0.05 level. The arrows mark three different working points—WP1, WP2, and WP3 (which correspond to the red, orange, and yellow dots/boxes in this figure)—that will be studied in detail.

doi: https://doi.org/10.1371/journal.pcbi.1008144.g003