Modeling microbial cross-feeding at intermediate scale portrays community dynamics and species coexistence
Fig 4
Impacts of amino acid supplementation on ecological relationships between two amino acid cross-feeders.
(A) The simulated steady-state phase diagram for different levels of amino acid supplementation. (B) Representative system dynamic trajectories of specific phases in (A). ΔGR: the difference between growth rate when set by amino acid as the sole limiting factor and when set by glucose as the sole limiting factor (the minimum of the two determines the actual growth rate). A positive or negative value of ΔGR indicates that cell growth is limited by glucose or amino acid respectively. (C) The isosurface of equal net growth rate (growth rate minus mortality rate) between the lysine and leucine auxotrophies. The dashed lines (blue and green) indicate when their net growth rates are equal to 0.1 h-1 (the dilution rate used throughout the figure). Abbreviations: glucose (G); lysine (K); leucine (L); lysine auxotroph (ΔK); leucine auxotroph (ΔL).