Overlaid positive and negative feedback loops shape dynamical properties of PhoPQ two-component system
Fig 6
Removing upregulation of mgrB can result in oscillations in the two component system.
A—Model schematic of an in silico mutant expressing mgrB constitutively instead of being expressed from the PhoP-P dependent promoter PmgrB B—Simulations of PhoP-P following a switch from high (50 mM) to intermediate (1 mM) Mg2+ show oscillations if mgrB is expressed at constant but low levels. Oscillations are absent in wild-type models, as well as models expressing mgrB at a constant high rate.